I run VB under Lenny, W2K, for a specialist CAD program. Works perfectly. Would probably work better with more memory, the rest of the system does slow down a bit. Only have 1G of which 512 is allocated to the VM.
I can't get shared folders to work, which is tiresome, so I email files back and forth - once they are exported in dxf they can be worked on in QCAD.
Peter